Need good results?
Start with a good preparation
The optimal frozen section begins with an evenly and completely frozen tissue block in which the block face that will be sectioned is flat and includes a complete, full faced section of the tissue submitted.
The section should be free of ice crystal artifacts, knife lines, and/or tears. The speed and simplicity of PrestoCHILL's operations revolutionize the rapid freezing process, keeping the microscopic appearance of tissues “true-to-life”.
What sets us apart?
The unique combination of the patented face-down embedding technique, together with a state-of-the-art, rapid stirling cooling device at -40°c.
This is how cryoembedding should be!
- No freezing artifacts
- 60 seconds freezing time
- An all-dry system
- Full downloadable documentation
- No liquid nitrogen
- No Co2 - No isopentane
Time to redefine
PrestoCHILL reduces freezing time to 60 seconds: it eliminates freezing artifacts through ultrafast freezing, preventing the formation of ice crystals.
Cut fatty tissues like breast or lymph nodes can be freezed without any sort of difficulty and without the distortion of delicate honeycomb structures.
It is possible to obtain perfectly “flat plane” surfaces to reduce trimming time and to cut easily while using the patented* “face down” embedding technique.
Moreover, it eliminates the compression of artifacts caused by extremely low temperatures and it removes the retraction of tissues: for example, Glomeruli from Bowman’s capsule, and vacuolation spaces around nucleated brain cells, related to formaline fixed, paraffin embedded (FFPE) sections.
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Simple AND Intuitive operationS make everyone an expert
The Milestone Application Team has distilled their know-how of several years of research and development of PrestoCHILL into Best Operating Procedures (BOP) for special applications.
They are a step-by-step very easy application guidelines supported also by video tutorials.
BOP101How to identify frozen specimens
BOP102How to freeze breast and fatty tissues
BOP103How to simultaneously freeze small specimens
BOP104How to freeze long-thin specimens
BOP105How to freeze muscle tissues
BOP106How to freeze thin specimens on edge
BOP107How to freeze multiple thin specimens on edge
BOP108How to freeze skin for MOHS surgery
BOP109How to freeze body fluids
Excellent quality with the PRESTO system
Lung Cancer 40X
Breast Cancer 40X
During the practice of frozen section pathology, pathologists often encounter the task of embedding tissues that are extremely delicate because of the nature of their consistence and structure. This is a situation that occurs daily during Mohs surgery, in which the technologist handles delicate slivers of skin with the goal of accurately embedding these tissues to completely visualize the epidermis and its margin. The PrestoCHILL paper embedding technique offers a safe and rapid solution to these problems.
Two innovative techniques are now available
1 PrestoCHILL paper embedding technique offers a safe and rapid solution to the difficult handling of delicate slivers of skin with the goal of accurately embedding these tissues to fully visualize the epidermis and its margins.
2 PrestoCHILL also offers an alternative technique with rings for those who prefer working with a wide -40C plate when ensuring margins adherence. This technique works seamlessly also with very challenging skin samples.
Take a look at the comparisons of outcomes
Cryoembedding on edge
With the help of a strip of cellulose it is possible to freeze the specimen on edge with the standard freezing procedure as paper disk cryoembedding.
High throughput operations
Each mold can be separately timed through the built-in control panel.
Up to 6 samples can be frozen in parallel or in sequential order in less than 4 minutes.
24/7 operations with fully automatic defrost feature
To eliminate the potential formation of ice on the freezing platform, an automatic defrost cycle is provided. It consists of an embedded heater in the freezing platform and a vacuum pump to extract water vapors from the chamber. Vapors are condensed and collected in a cold-trap placed in the front of the unit for easy handling. A HEPA filter is provided on the exhaust side of the pump. Integrated software can set the defrost cycle to take place during off hours. Afterwards, the cooling cycle automatically restarts at a preset time to ensure the availability for the first case of the day, removing the need to manually monitor the system.